Comprehensive immunoinformatics and bioinformatics strategies for designing a multi-epitope based vaccine targeting structural proteins of Nipah virus.

ABSTRACT:

Background

Nipah virus (NiV) is characterized by recurring outbreaks and causes severe neurological impact, leading to increased mortality rates. Despite the severity of the disease, there is no proven post-exposure treatment available, emphasizing the critical need for the development of an effective vaccine.

Objective

This study was aimed at designing a multi-epitope based vaccine candidate based on an in-silico approach.

Methods

NiV's Structural proteins were screened for B and T-cell epitopes, assessing characteristics like antigenicity, immunogenicity, allergenicity, and toxicity. Two vaccine constructs (NiV_1 & 2) were designed using different adjuvants (Cholera toxin and Beta-defensin 3) and linkers and their predicted 3D structures were evaluated for interacti

SUBMITTER: Sharma S 

PROVIDER: S-EPMC12106399 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature