Exploiting subtractive genomics to identify novel drug targets and new immunogenic candidates against <i>Bordetella pertussis</i>: an <i>in silico</i> study.

ABSTRACT:

Background

Bordetella pertussis, the causative agent of whooping cough, remains a significant global health concern despite the widespread availability of vaccines. The persistent reemergence of pertussis is driven by the bacterium's ongoing genomic evolution, shifting epidemiological patterns, and limitations in current vaccine strategies. These challenges highlight the urgent need to identify novel drug targets and immunogenic candidates to enhance therapeutic and preventive measures against B. pertussis.

Methods

Identification of novel drug targets and the detection of immunogenic factors as potential vaccine candidates were performed. Cytoplasmic proteins were evaluated for their similarity to the human proteome, metabolic pathways, and gut microbiota. On t

SUBMITTER: Khazani Asforooshani M 

PROVIDER: S-EPMC12106433 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature