Involvement of the <i>bla</i> _CTX-M-3 gene in emergence of a peculiar resistance phenotype in <i>Klebsiella pneumoniae</i>.

ABSTRACT:

Introduction

This study aimed to investigate the mechanism underlying a peculiar resistance phenotype in Klebsiella pneumoniae, characterized by reduced susceptibility to cefepime compared to ceftazidime.

Methods

Antimicrobial susceptibility testing, plasmid conjugation experiments, whole-genome sequencing, and bioinformatic analyses were employed to characterize the resistance phenotype and identify genetic determinants.

Results

A total of 20 K. pneumoniae strains exhibiting peculiar resistance phenotypes were collected and analyzed. Ten distinct sequence types (STs) were identified, including ST25 (4/20), ST967 (3/20), ST65 (2/20), ST133 (2/20), ST48 (2/20), ST353 (1/20), ST628 (1/20), ST753 (1/20), ST792 (1/20), and ST254 (1/20). All strains were resi

SUBMITTER: Li P 

PROVIDER: S-EPMC12106457 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature