Uncovering dendritic cell specific biomarkers for diagnosis and prognosis of cardiomyopathy using single cell RNA sequencing and comprehensive bioinformatics analysis.

ABSTRACT: Cardiomyopathy is a type of cardiovascular disorder that is a primary cause of death globally, killing millions of people each year. Cardiomyopathy detection and early diagnosis are crucial in reducing negative health effects. Thus, this study aims to use single cell RNA sequencing, and bioinformatics analysis to uncover dendritic cell-specific biomarkers, gene ontology, pathways, regulatory interaction networks, and protein-chemical compounds related to the molecular mechanism of cardiomyopathy progression. Two RNAseq datasets GSE65446 and GSE155495 also were evaluated to identify significant biomarkers in cardiomyopathy, and 123 mutual DEGs appeared between scRNAseq and RNAseq datasets. In addition, the DAVID online platform and FunRich software were utilized to detect cell communication

SUBMITTER: Rahman MM 

PROVIDER: S-EPMC12106800 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature