Sidedness in Unilateral Orofacial Clefts: A Systematic Scoping Review.

ABSTRACT: ObjectiveAn overview of the literature relating to the sidedness of unilateral cleft lip with or without cleft palate to map current knowledge on the cause and impact of directional asymmetry.DesignScoping review with a systematic search of Medline and Embase from inception to May 2023.Patients, ParticipantsHumans born with a left or right unilateral cleft lip with or without a cleft palate.Main Outcome MeasuresCleft sidedness as a co-occurrence, an outcome or an exposure.ResultsForty studies were eligible for inclusion and confirmed the predilection for the occurrence of left sided cleft lips; 12 studies reported cleft sidedness co-occurring with another phenotype, 11 studies report sidedness as an outcome and 17 studies as an exposure. Phenotypes which were reported to co-occur with eith

SUBMITTER: Fell M 

PROVIDER: S-EPMC12106926 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature