Genetically-determined variation in CRP impacts disease activity assessment in rheumatoid arthritis.

ABSTRACT:

Objectives

In patients with RA, we evaluated a single-nucleotide variant previously associated with lower CRP to assess if this impacts clinical disease activity assessments including the disease activity score-28 with CRP (DAS28(CRP)).

Methods

Patients from three observational cohorts were evaluated-the United Kingdom Biobank (UKB), the Veterans Affairs RA Registry (VARA) and the FORWARD Databank. The effect of rs1205 genotype on log-adjusted serum CRP concentrations was assessed using linear regression adjusted for sex, age and population structure. The regression coefficients from UKB were converted to create a modified CRP and DAS28(CRP). Reclassification to an abnormal CRP (>0.8 mg/dl) and between DAS28(CRP) disease activity groups were determined.

Results

Among

SUBMITTER: Riley TR 

PROVIDER: S-EPMC12107066 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature