Exact and efficient phylodynamic simulation from arbitrarily large populations.

ABSTRACT: Many biological studies involve inferring the evolutionary history of a sample of individuals from a large population and interpreting the reconstructed tree. Such an ascertained tree typically represents only a small part of a comprehensive population tree and is distorted by survivorship and sampling biases. Inferring evolutionary parameters from ascertained trees requires modeling both the underlying population dynamics and the ascertainment process. A crucial component of this phylodynamic modeling involves tree simulation, which is used to benchmark probabilistic inference methods. To simulate an ascertained tree, one must first simulate the full population tree and then prune unobserved lineages. Consequently, the computational cost is determined not by the size of the final simulate

SUBMITTER: Celentano M 

PROVIDER: S-EPMC12107099 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature