Myelin sheaths can act as compact temporary oxygen storage units as modeled by an electrical RC circuit model.

ABSTRACT: Oxygen is crucial for mitochondrial energy production in neurons and is efficiently stored and transported within the hydrophobic core of phospholipid bilayers. Using a diffusive model derived from molecular dynamics simulations, we demonstrate that oxygen storage in a bilayer follows first-order kinetics, which can be effectively represented by an RC (resistor-capacitor) circuit. For myelin, with multiple bilayers, oxygen transport is modeled through a ladder network of RC circuits, where oxygen permeation resistance and oxygen storage capacity scale linearly with bilayer count. Meanwhile, the characteristic time constant scales quadratically with myelin thickness, e.g. enhancing the characteristic time constant from 30 ns for one 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) bi

SUBMITTER: Vervust W 

PROVIDER: S-EPMC12107128 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature