Real-world implementation of a noninvasive, AI-augmented, anemia-screening smartphone app and personalization for hemoglobin level self-monitoring.

ABSTRACT: Anemia, characterized by low blood hemoglobin (Hgb) levels, afflicts >2 billion individuals worldwide. Here, we report real-world data generated by a smartphone app that noninvasively screens for anemia using only "fingernail selfies." App data for anemia screening were obtained from >1.4 million uses across the United States enabling geographic mapping of Hgb levels. Of those, 9,061 users also self-reported complete blood count Hgb levels for comparison, resulting in accuracy and performance that match gold standard laboratory testing and a sensitivity and specificity of 89% and 93%, respectively, when using an anemia cutoff of 12.5 g/dL. Geotagged data enabled construction of an "anemia map" of the United States, which demonstrated that Hgb levels correlate with socioeconomic status, and

SUBMITTER: Mannino RG 

PROVIDER: S-EPMC12107174 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature