Association of <i>APOE</i> genotype with CT markers of cerebral amyloid angiopathy in spontaneous intracerebral haemorrhage.

ABSTRACT:

Background and objective

We investigated the association of APOE alleles with CT-based cerebral amyloid angiopathy (CAA) markers including subarachnoid extension (SAE) and finger-like projection (FLP).

Methods

We included patients with acute primary supratentorial intracerebral haemorrhage (ICH) from a multicentre cohort in China. First, the association of APOE with ICH location (lobar vs non-lobar) was evaluated. Next, the relationships of APOE with SAE, FLP, and the coexistence of the two (SAE+FLP) were evaluated.

Results

533 patients with supratentorial ICH were enrolled. Among them were 138 patients with lobar ICH and 395 with non-lobar ICH. Compared with the non-lobar group, APOE ε4 (OR 1.894, 95% CI 1.138 to 3.154, p=0.014) and ε2/ε4

SUBMITTER: Yang Q 

PROVIDER: S-EPMC12107438 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature