Integrating genome-wide information and wearable device data to explore the link of anxiety and antidepressants with pulse rate variability.

ABSTRACT: This study explores the genetic and epidemiologic correlates of long-term photoplethysmography-derived pulse rate variability (PRV) measurements with anxiety disorders. Individuals with whole-genome sequencing, Fitbit, and electronic health record data (N = 920; 61,333 data points) were selected from the All of Us Research Program. Anxiety polygenic risk scores (PRS) were derived with PRS-CS after meta-analyzing anxiety genome-wide association studies from three major cohorts- UK Biobank, FinnGen, and the Million Veterans Program (N_Total =364,550). PRV was estimated as the standard deviation of average five-minute pulse wave intervals over full 24-hour pulse rate measurements (SDANN). Antidepressant exposure was defined as an active antidepressant prescription at the time of the

SUBMITTER: Friligkou E 

PROVIDER: S-EPMC12107450 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature