PRCP is a promising drug target for intracranial aneurysm rupture supported via multi-omics analysis.

ABSTRACT:

Background

Cerebral aneurysms are life-threatening cerebrovascular disorders. Currently, there are no effective treatments for preventing disease progression. Mendelian randomisation (MR) is widely used to repurify licensed drugs and identify new therapeutic targets. Therefore, this study aims to investigate effective drug targets for preventing the formation and rupture of cerebral aneurysms and analyse their potential mechanisms.

Methods

We performed a comprehensive study integrating two-sample MR analysis, colocalisation analysis and summary data-based Mendelian randomisation (SMR) to assess the causal effects of blood and brain druggable cis-expression quantitative trait loci (cis-eQTLs) on intracranial aneurysm (IA), unruptured intracranial aneurysm (UIA) and subarachno

SUBMITTER: Wu J 

PROVIDER: S-EPMC12107461 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature