Development and validation of a time-varying correction factor for QT interval assessment in drug-resistant tuberculosis patients.

ABSTRACT:

Background

Tachycardia associated with active tuberculosis (TB) often diminishes when patients recover from TB. Elevated heart rate (HR) may lead to suboptimal correction, complicating the assessment of QT prolongation when using standard correction factors (CFs), such as Fridericia's formula (QTcF). Olliaro has proposed a CF for QT interval correction in pretreatment TB patients. However, the QT-HR correlation changes as HR decreases during treatment, indicating the need for time-varying correction.

Methods

We developed an HR model to capture the HR normalisation during successful treatment. Subsequently, a time-varying CF was constructed using the estimated HR change rate. The performance of CFs to make corrected QT (QTc) independent from HR was evaluated by linear regress

SUBMITTER: Vongjarudech T 

PROVIDER: S-EPMC12107617 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature