Metformin for covid-19: systematic review and meta-analysis of randomised controlled trials.

ABSTRACT:

Objective

To summarise the effects of metformin on covid-19 to inform a World Health Organization (WHO) clinical practice guideline.

Design

Systematic review and meta-analysis.

Data sources

As part of a living systematic review and network meta-analysis of drug treatments for covid-19 (covid-19 LNMA), a search was performed of the WHO covid-19 database, six Chinese databases, and the Epistemonikos Foundation's Living Overview of the Evidence covid-19 Repository (covid-19 L-OVE).

Eligibility criteria for selecting studies

Randomised controlled trials that compared metformin with placebo in patients with acute covid-19 infection.

Data synthesis

Frequentist pairwise meta-analyses were performed using the restricted maximum likelihood random effects model. T

SUBMITTER: Chowdhury SR 

PROVIDER: S-EPMC12107632 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature