Protein co-aggregates of dense core amyloid plaques and CSF differ in rapidly progressive Alzheimer's disease and slower sporadic Alzheimer's disease.

ABSTRACT:

Background

The rapidly progressive phenotype of Alzheimer's disease (rpAD) remains a rare and less-studied entity. Therefore, the replication of key results from the rpAD brain and cerebrospinal fluid (CSF) is lacking.

Methods

A label-free quantitative LC-MS/MS analysis of proteins co-aggregating with core-amyloid β plaques in fresh frozen tissue (FFT) from medial temporal regions of rpAD ( n=8 ) neuropathologically characterized at the National Prion Disease Pathology Surveillance Center (NPDPSC), compared with microdissected amyloid plaques from formalin-fixed, paraffin-embedded (FFPE) tissue blocks from patients with rpAD ( n=22 ) previously published from the NPDPSC cohort, was performed. Matched rpAD CSF from the FFT cases were compared to a previously published proteom

SUBMITTER: Bebek G 

PROVIDER: S-EPMC12107742 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature