Tumour-associated macrophage infiltration differs in meningioma genotypes, and is important in tumour dynamics.

ABSTRACT:

Background

Meningiomas are the most common primary intracranial tumours, with clinical behaviours ranging from benign to highly aggressive forms. The World Health Organisation classifies meningiomas into various grades, guiding prognosis and treatment. While surgery is effective for low-grade meningiomas, certain grade 1 tumours, as well as grade 2, 3, and recurrent cases are more aggressive and require new therapeutic approaches. Immunotherapy shows promise, with early-stage clinical trials demonstrating encouraging results. The tumour microenvironment (TME), particularly tumour-associated macrophages (TAMs), plays a pivotal role in tumour progression. TAMs influence tumour growth, metastasis, and immune evasion. However, their role in meningiomas, especially in relation to genomi

SUBMITTER: Zhang T 

PROVIDER: S-EPMC12107748 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature