A virulent escherichia coli O121-B2-ST131 strain causes hemorrhagic pneumonia in mink: evidence from pathogenicity and animal challenge experiments.

ABSTRACT: In recent years, rapid fatal hemorrhagic pneumonia (HP) has been increasingly reported in mink. In several studies, the virulence factors of strains isolated from diseased tissues have been identified as extraintestinal pathogenic Escherichia coli (ExPEC). The molecular characteristics of the strains were also analyzed, but whether ExPEC is the etiological agent of HP has not been confirmed in an animal challenge model. In this study, we characterized the antibiotic resistance, virulence characteristics, and pathogenicity of a bacterial strain isolated from a typical case of mink HP, and designated it L1. Our study revealed that isolate L1 has high levels of antibiotic resistance, to multiple antibiotics, including ampicillin, tylosin, kanamycin, and so on. Numerous virulence genes were de

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12107772 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature