Radiation-induced brain injury in non-human primates: A dual tracer PET study with [¹¹C]MPC-6827 and [¹¹C]PiB.

ABSTRACT: Radiation-induced brain injury (RIBI) and Alzheimer's disease (AD) share key pathological features, including β-amyloid (Aβ) plaque formation and microtubule (MT) destabilization, both contributing to neurodegeneration. This pilot study assessed Aβ deposition and MT stability in non-human primates (NHPs) exposed to ionizing radiation, utilizing [¹¹C]PiB and [¹¹C]MPC-6827 PET imaging to explore neurodegenerative mechanisms. Fourteen rhesus macaques, seven irradiated and seven controls underwent PET imaging. Tracers were synthesized and brain regions (ex. cingulate, hippocampus, and occipital lobe) were analyzed for tracer uptake. Although no statistically significant whole-brain differences in tracer uptake were found between irradiated and control groups, significant

SUBMITTER: Damuka N 

PROVIDER: S-EPMC12108029 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature