Protein-specific immune response elicited by the <i>Shigella sonnei</i> 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to <i>Shigella</i>.

ABSTRACT: Shigella is a leading cause of diarrheal morbidity and mortality in young children from low- and middle-income countries. Here, we aimed to verify the ability of the generalized modules for membrane antigens (GMMA)-based Shigella sonnei candidate vaccine 1790GAHB to elicit an anti-protein antibody response. Serum samples from previous clinical trials in adults (a dose-escalation study and its extension in France, a vaccine efficacy study after human challenge in the United States, and a study in Kenya) were investigated using pan-proteome microarrays consisting of 3,150 full-length or fragmented Shigella proteins. Pre-/post-vaccination comparisons identified subsets of proteins that were highly immunoreactive and largely overlapped across all trials; the T3SS lipochape

SUBMITTER: Randall AZ 

PROVIDER: S-EPMC12108075 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature