Aging Selectively Alters PRR and ISG Expression in Endo- and Ecto-Cervical Stromal Fibroblasts From the Human Female Reproductive Tract.

ABSTRACT:

Problem

Aging alters immune function in women and can lead increased risk of infections, particularly in the female reproductive tract (FRT).

Method of study

To determine how aging affects innate immune responses in the cervical stroma of the FRT, we isolated endocervical (CX) and ectocervical (ECX) stromal fibroblasts and determine if their expression of multiple pattern recognition receptors (PRRs) and responses to viral stimulation varied with menopause and age.

Results

Constitutive expression of most PRRs did not vary with age or menopausal status in either cell type. However, the expression of TLR7, MDA5, and NOD2 by ECX stromal fibroblasts significantly increased in post-menopausal women, while the expression of NOD1 by CX stromal fibroblast also significantly i

SUBMITTER: Patel MV 

PROVIDER: S-EPMC12108118 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature