Pharmacokinetic Characteristics of a Single Cannabidiol Dose in Oil and Treat Forms and Health Impacts After 30 Days of Administration in Dogs.

ABSTRACT: Cannabidiol (CBD) has garnered significant interest in veterinary therapeutics, yet the pharmacokinetic and safety profiles of its various formulations remain incompletely characterized. This study compared the pharmacokinetics (PK) and health effects of CBD administered as oil (OG, 5 mg/kg) and treats (TG, 50 mg) in 16 healthy mixed-breed dogs over 30 days. Plasma CBD concentrations were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and the PK parameters were analyzed using non-compartmental methods. The CBD-infused rice bran oil formulation (OG) achieved a significantly higher dose-normalized maximum plasma concentration (C_max, 58.40 vs. 21.29 kg·ng/mL/mg) and area under the curve (AUC_0-inf, 305.85 vs. 141.75 h·kg·ng/mL/mg) compared to th

SUBMITTER: Kamutchat P 

PROVIDER: S-EPMC12108255 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature