Genetic Variation in the <i>blaZ</i> Gene Leading to the BORSA Phenotype in <i>Staphylococcus aureus</i>.

ABSTRACT:

Background/objectives

Staphylococcus aureus is a leading cause of bacteraemia in Danish hospitals. Approximately 70% of clinical S. aureus isolates are penicillin-resistant, which is predominantly due to blaZ-mediated β-lactamase production.

Methods

A collection of 489 S. aureus strains derived from bacteraemia were cultured and their genomes sequenced.

Results

From this collection, 71% of isolates were methicillin-susceptible S. aureus (MSSA) harbouring blaZ. While most isolates contained the blaZ gene belonging to the well-characterised A, B, C and D variants, three strains (1%) produced a BlaZ protein characterised by having threonine residues on both positions 128 and 216 and, therefore, belonged to neither of the e

SUBMITTER: Aarris M 

PROVIDER: S-EPMC12108325 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature