Novel benzimidazole hybrids: design, synthesis, mechanistic studies, antifungal potential and molecular dynamics.

ABSTRACT: In this study, two series of benzimidazole hybrids were developed and designed using different strategies. The target compounds were designed through straight chemistry pathways and were screened as possible antimicrobial agents. Twenty new compounds were synthesized, among which compounds 11 and 12 displayed excellent activity against Candida albicans and Cryptococcus neoformans with growth inhibition percentage ranging from 86.42% to 100%. For gaining better insights into the mechanistic ability of the active candidates 11 and 12, their inhibitory activity against lanosterol 14α-demethylase was studied. Results showed IC₅₀ values of 5.6 and 7.1 μM for 11 and 12, respectively, which were comparable to the reference value of fluconazole (2.3 μM), indicating low dru

SUBMITTER: Ibrahim AA 

PROVIDER: S-EPMC12108968 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature