Integrative Transcriptomic Profiling Identifies <i>TNF</i> and <i>IL1B</i> as Candidate Key Early-Response Genes in Macrophages Infected with Smooth <i>Brucella</i> Using a Comprehensive Bioinformatic Approach.

ABSTRACT: Smooth Brucella are the main pathogenic bacteria that threaten human health and food safety. The early stage of smooth Brucella and macrophage interaction is an important phase, and smooth Brucella species elicit a dramatic transcriptional response in infected macrophages. However, the key transcriptional events are still obscure. This study aimed to identify key candidate response pathways and genes in macrophages infected with smooth Brucella at the early interaction stage. Three gene expression profiles including GSE21117, GSE5202, and GSE8385 were retrieved from the NCBI GEO database, and were integrated using comprehensive bioinformatics methods including gene set enrichment analysis, differentially expressed gene analysis, protein and protein interaction (

SUBMITTER: Yang X 

PROVIDER: S-EPMC12109160 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature