Transcriptome and Metabolome Analyses Reveal High-Altitude Adaptation in the Qinghai Toad-Headed Lizard <i>Phrynocephalus vlangalii</i>.

ABSTRACT: The plateau environments are always harsh, with low pressure, low oxygen, and low temperature, which are detrimental to the survival of organisms. The Qinghai toad-headed lizard Phrynocephalus vlangalii has a wide range of altitude adaptation from 2000 to 4600 m. But it is still unclear how organisms maintain tissue function by balancing energy supply and demand changes in high-altitude environments of P. vlangalii. We investigated the plateau metabolic adaptation through transcriptome and metabolome analyses of P. vlangalii from three populations at different altitudes of the Qinghai-Tibet Plateau. The genes related to carbohydrate metabolism were significantly down-regulated at the high altitude. The metabolites alpha-D-glucose 1-phosphate, beta-D-fructose 6-phosphat

SUBMITTER: Zhong J 

PROVIDER: S-EPMC12109203 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature