Pancreatic MicroRNAs in <i>Ictidomys tridecemlineatus</i> Associated with Metabolic Diseases: Nature's Insights into Important Biomarkers.

ABSTRACT: Hibernation involves a profound metabolic rate depression (MRD) that enables certain species to survive prolonged periods of low energy availability. The thirteen-lined ground squirrel uses MRD to arrange cellular and biochemical pathways which suppress nonvital genetic and cellular pathways to conserve internal energy while preserving all essential processes. This study investigates the role of microRNAs (miRNAs) in controlling key signaling pathways and cellular processes in pancreatic tissue during hibernation. Using next-generation sequencing and broad genomic analysis, we analyzed and identified seven differentially expressed miRNAs (miR-29a-3p, miR-22-3p, miR-125-5p, miR-200a-3p, miR-328-3p, miR-21-5p, and miR-148-3p) in the pancreas of hibernating 13-lined ground squirrels (Ictid

SUBMITTER: Taiwo OO 

PROVIDER: S-EPMC12109365 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature