Novel Biomarkers in Hepatocellular Carcinoma from Embryogenic Antigens to cfDNA.

ABSTRACT: Background: Hepatocellular carcinoma (HCC), a primary liver cancer, continues to pose a significant challenge to the healthcare system because of its elevated incidence and fatality rates. This study aims to assess new biomarkers for early diagnosis and prognosis, comparing them to the established gold standard alpha-fetoprotein (AFP) and liver ultrasonography. Methods: A literature review was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guideline. A total of 670 papers were identified using internet databases. After applying the exclusion criteria, eight studies were included in this literature review. Results: It was identified that certain analyzed biomarkers, or the combinations thereof, exhibited supe

SUBMITTER: Ghantus R 

PROVIDER: S-EPMC12109373 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature