Genetic Variation and Gene Expression of the Antimicrobial Peptide Macins in Asian Buffalo Leech (<i>Hirudinaria manillensis</i>).

ABSTRACT: With the growing severity of antibiotic resistance, antimicrobial peptides demonstrate significant potential for medical applications. Here, we performed genome and transcriptome sequencing of 30 Asian buffalo leech (Hirudinaria manillensis) individuals and integrated data from three other leech species (Whitmania pigra, Hirudo nipponia, and Hirudo medicinalis) to investigate genetic variation and gene expression of H. manillensis macins. Three macins (Hman1, Hman2, and Hman3), along with their encoding genes (Hman1, Hman2, and Hman3), were identified in H. manillensis. Hman1 exhibited the highest similarity (63.5 ± 12.0%) to macins from other leeches, followed by Hman2 (57.8 ± 7.4%) and Hman3 (30.0 ± 3.5%). Both amino acid and

SUBMITTER: Yu Y 

PROVIDER: S-EPMC12109416 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature