Transposable Element Is Predictive of Chemotherapy- and Immunotherapy-Related Overall Survival in Glioma.

ABSTRACT: Background: Glioma is the most common type of malignant brain tumor. Temozolomide (TMZ) is a limited systematic treatment option for glioma, including low-grade glioma (LGG) and glioblastoma (GBM). However, not all patients benefit from TMZ and some develop resistance to it. MGMT methylation has been used to identify patients who may benefit from TMZ, but it is not effective in all cases. Objectives: There is an urgent need for new biomarkers to predict the survival of patients who receive TMZ. Methods: We utilized a recently developed method called REdiscoverTE to precisely measure the expression of transposable elements (TE). We performed Cox regression analysis to assess the predictive ability for prognosis and conducted a series of correlation studies to uncover po

SUBMITTER: Peng B 

PROVIDER: S-EPMC12109447 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature