LIFR-Mediated ERBB2 Signaling Is Essential for Successful Embryo Implantation in Mice.

ABSTRACT: In eutherian mammals, embryo implantation is a critical process for a successful pregnancy. In mice, the activation of the leukemia inhibitory factor (LIF) receptor-STAT3 signaling axis induces embryo adhesion and decidualization. The LIF receptor is believed to function as a heterodimer composed of LIFR (encoded by Lifr) and GP130 (encoded by Il6st); however, their distinct expression patterns in the uterine epithelium immediately prior to implantation suggest divergent functional roles. In this study, we generated uterine epithelium-specific Lifr knockout (Lifr eKO) mice and conducted a comprehensive gene expression analysis of the endometrium before implantation. We compared these results with those from uterine epithelium-specific Gp130 knockout (G

SUBMITTER: Terakawa J 

PROVIDER: S-EPMC12109566 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature