Glutathione Peroxidase 4 in Blunt Snout Bream (<i>Megalobrama amblycephala</i>) Regulates Ferroptosis and Inflammation in Response to <i>Aeromonas hydrophila</i> Infection.

ABSTRACT: Glutathione peroxidase 4 (GPX4) plays a crucial role in regulating lipid peroxidation and is associated with infection and inflammation, particularly in terms of its effects on inflammatory cytokines and ferroptosis. This study aimed to investigate the regulatory effects of Gpx4 on the inflammatory response and ferroptosis in blunt snout bream (Megalobrama amblycephala), a significant freshwater fish species in China, after Aeromonas hydrophila infection. Using a bioinformatics analysis, we discovered that Gpx4 has a conserved protein structure and high amino acid identity in various carp species, indicating functional conservation across species and through involution. RT-qPCR analysis revealed that gpx4 mRNA increased after the neuroembryonic stage during early devel

SUBMITTER: He M 

PROVIDER: S-EPMC12109816 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature