<i>Daphne kiusiana</i> Crude Extract and Its Fraction Enhance Keratinocyte Migration via the ERK/MMP9 Pathway.

ABSTRACT: Daphne kiusiana is a naturally occurring plant in East Asia belonging to the Thymelaeaceae family. While its biological properties have been explored, its potential role in wound healing remains largely unknown. This study investigated the effects of Daphne kiusiana extracts on keratinocyte migration and the underlying mechanisms. The crude extract and its fractions was tested in vitro at various concentrations to evaluate their ability to promote keratinocyte migration, and a cytotoxicity assay was conducted to assess cell viability. The results demonstrated that Daphne kiusiana significantly enhanced keratinocyte migration without inducing notable cytotoxicity at tested concentrations. Mechanistically, this effect was mediated through the modulation of matrix metallo

SUBMITTER: Lee J 

PROVIDER: S-EPMC12110485 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature