Gene Expression Differences Based on Low Total 25(OH)D and Low VDBP Status with a Preterm Birth.

ABSTRACT: Preterm birth (PTB; <37 weeks' gestation) is a persistent problem in the United States that affects non-Hispanic Black women at much higher rates than White women. Several biomarkers have been associated with PTB, including vitamin D deficiency (VDD) and low levels of vitamin D-binding protein (VDBP). However, no biomarker has been found to predict PTB. To identify a predictive biomarker of PTB, gene expression differences were determined in Black women with PTB and full-term births and between women with high and low levels of plasma vitamin D and high and low VDBP levels. In this pilot study of 19 pregnant women from the Biosocial Impact on Black Births (BIBB) study, we found that 47 genes were upregulated and 16 genes were downregulated in women with PTB as compared with women who had a

SUBMITTER: Woo J 

PROVIDER: S-EPMC12110801 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature