Phylogenomic and Evolutionary Insights into Lipoprotein Lipase (LPL) Genes in Tambaqui: Gene Duplication, Tissue-Specific Expression and Physiological Implications.

ABSTRACT:

Background/objectives

Lipoprotein lipase (LPL) is a key enzyme in lipid metabolism, crucial for the hydrolysis of triglycerides in lipoproteins and maintaining lipid homeostasis in vertebrates. This study aims to characterize the lipoprotein lipase genes in the tambaqui (Colossoma macropomum) genome, investigating their evolutionary history from a phylogenomic perspective.

Methods

Phylogenetic and syntenic analyses were used to identify the lpl gene copies in the tambaqui genome and expression patterns were examined across different tissues. A comparative analysis with lpl genes from other vertebrates was also conducted to assess evolutionary relationships and functional diversification.

Results

We identified three lpl gene copies in the ta

SUBMITTER: Paixao RV 

PROVIDER: S-EPMC12111056 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature