Genetic Background and Gene Essentiality.

ABSTRACT:

Background/objectives

Essential genes are those required for an organism's survival and reproduction. However, gene essentiality is not absolute; it can be highly context-dependent, varying across genetic and environmental conditions. Most previous studies have assessed gene essentiality in a single genetic background, limiting our understanding of its variability. The objective of this study was to investigate how genetic background influences gene essentiality in the multicellular model organism Caenorhabditis elegans.

Methods

We examined gene essentiality in three genetically distinct C. elegans strains: N2, LKC34, and MY16. A total of 294 genes were selected for RNA interference (RNAi) knockdown: 101 previously classified as essential, 175 as nonessential a

SUBMITTER: Gasienica P 

PROVIDER: S-EPMC12111165 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature