Zebrafish <i>cdh23</i> Affects Rod Cell Phototransduction Through Regulating Ca²⁺ Transport and MAPK Signaling Pathway.

ABSTRACT: Mutations in the pathogenic gene CDH23 are known to cause Usher syndrome, affecting both auditory and visual functions. Our previous results provided valuable insights into the mechanisms underlying congenital hearing loss associated with CDH23 mutations. However, the molecular mechanisms and signaling pathways that influence vision remain largely unknown. In this study, transcriptional sequencing and bioinformatics analysis were conducted to compare gene expression between the control and cdh23^-/-. Additionally, RT-qPCR experiments were performed to further validate the bioinformatics analysis results. The comparative transcriptomic analysis identified differentially expressed genes associated with photoreceptor degeneration and the mitogen-activ

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12111248 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature