Characterizing the Social Epigenome in Mexican Patients with Early-Onset Psychosis.

ABSTRACT: Background: Psychosis is one of the leading causes of disability worldwide. Individuals with early-onset psychosis (EOP) tend to experience a worse prognosis and shorter life expectancy. The etiology of EOP remains unclear, but epigenetic mechanisms are known to serve as the interface between environmental exposures and biological processes to better understand its etiology. Objectives: We characterized the sociodemographic and clinical characteristics, as well as genome-wide epigenetic markers, in Mexican patients with EOP. Methods: We estimated epigenetic age, performed an epigenome-wide association study, and finally developed an epigenetic risk score (MRS) to predict manifestations of psychosis. Results: We found that patients with EOP have a higher epigenet

SUBMITTER: Ruiz-Ramos D 

PROVIDER: S-EPMC12111507 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature