In Vitro and In Silico Evaluation of the Potential Anti-Prostate Cancer Activity of <i>Rosmarinus officinalis</i> L. Leaf Extracts.

ABSTRACT: Prostate cancer is one of the most prevalent cancer types diagnosed in older men. Investigations into traditional medicines like Rosmarinus officinalis L., popularly known as rosemary, are a current research interest due to its anti-cancer properties. This study investigates the cytotoxicity of aqueous and ethanolic rosemary leaf extracts in DU-145 cells and the interaction of its active metabolites with key prostate cancer targets using an in silico approach. The water extract of rosemary leaves showed greater cytotoxicity than the ethanol extract, with IC₅₀ values of 1.4140 ± 0.1138 mg/mL and 1.8666 ± 0.0367 mg/mL, respectively; the highest cytotoxic effects for both extracts were observed at 5 mg/mL. These findings indicate significant cytotoxic differences based on co

SUBMITTER: Austria SFB 

PROVIDER: S-EPMC12111643 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature