Eligibility and GDMT up-titration success in heart failure: A real-world assessment.

ABSTRACT:

Background

Implementation of GDMT in HFrEF remains incomplete. Prescription manners may vary based on the development of adverse effects. An HFA position paper proposed patient profiling and individualized prescription manners. This study aims to assess the eligibility for GDMT up-titration and its success in the context of clinical profiles in chronic severe HFrEF outpatients.

Methods

Clinical characteristics of 900 HFrEF patients at first presentation were assessed, and GDMT up-titration limiting factors were identified by applying thresholds of mutual consent. GDMT prescription was analyzed at 6 months and 1 year.

Results

75% of patients had no GDMT up-titration limiting factor at baseline. Significant up-titration could be achieved in all four HF drug classes, esp

SUBMITTER: Weidenhammer A 

PROVIDER: S-EPMC12112052 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature