On the Potential Role of Phytate Against Neurodegeneration: It Protects Against Fe³⁺-Catalyzed Degradation of Dopamine and Ascorbate and Against Fe³⁺-Induced Protein Aggregation.

ABSTRACT: Myo-inositol-1,2,3,4,5,6-hexakisphosphate (IP6) is commonly found in plant-derived foods and has important pharmacological properties against many pathologies. One of them appears to be neurodegeneration, which is notably stimulated by dysregulated metal metabolism. Consequently, we explore the role of IP6 in mitigating neurodegenerative events catalyzed by dysregulated free iron. More precisely, we performed spectrophotometric measurements in aqueous solutions to investigate the ability of IP6 to chelate Fe³⁺ and inhibit its role in catalyzing the oxidative degradation of dopamine and ascorbic acid, two key molecules in neuronal redox systems. Our results demonstrate that IP6 effectively prevents the formation of harmful intermediates, such as neuromelanin and reactive oxygen s

SUBMITTER: Godoy SR 

PROVIDER: S-EPMC12112605 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature