Polyketides with a 6/6/6/6 Oxaphenalene Pyranone Skeleton from Marine-Derived <i>Streptomyces</i> sp. HDN150000.

ABSTRACT: Three new structures named naphpyrone I-K (1-3) that contain a 6/6/6/6 oxaphenalene pyranone skeleton were isolated and purified from a marine-derived Streptomyces sp. HDN155000. Their chemical structures, including configurations, were elucidated by extensive NMR, MS, single-crystal X-ray diffraction, theoretical NMR calculations, DP4+ probability analysis, and ECD analyses. Naphpyrone K (3) showed cytotoxic activities against L-02, K562, NCI-H446/EP, MDA-MB-231, and NCI-H446 cancer cells with IC₅₀ values of 5.13, 3.34, 2.50, 2.61, and 2.20 μM, respectively. These findings highlight the potential for screening and developing therapeutic drugs from aromatic polyketides derived from marine actinobacteria.

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12112823 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature