Recurrent Vulvovaginal Candidosis and Its Underlying Mechanisms: A Systematic Review.

ABSTRACT: Recurrent vulvovaginal candidosis (RVVC), defined as three or more episodes of vulvovaginal candidosis (VVC) within a 12-month period, is a common and debilitating condition that affects a significant percentage of reproductive-aged women, negatively impacting their quality of life. This review aimed to synthesize the most recent scientific data on the pathophysiological mechanisms triggering primary or idiopathic RVVC. Three databases (PubMed, Scopus, and Web of Science) were searched for studies published between 2014 and 2024. Twelve studies were included, covering prospective cohort, cross-sectional, and case-control studies conducted in different countries. The results indicate that recurrence may be related to both intrinsic characteristics of the pathogen, such as increased virulenc

SUBMITTER: Lobo M 

PROVIDER: S-EPMC12112908 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature