<i>Pseudogymnoascus destructans</i> Transcriptional Response to Chronic Copper Stress.

ABSTRACT: Copper (Cu) is an essential metal micronutrient, and a fungal pathogen's ability to thrive in diverse niches across a broad range of bioavailable copper levels is vital for host colonization and fungal propagation. Recent transcriptomic studies have implied that trace metal acquisition is important for the propagation of the white nose syndrome (WNS) causing fungus, Pseudogymnoascus destructans, on bat hosts. This report characterizes the P. destructans transcriptional response to Cu-withholding and Cu-overload stress. We identify 583 differently expressed genes (DEGs) that respond to Cu-withholding stress and 667 DEGs that respond to Cu-overload stress. We find that the P. destructans Cu-transporter genes CTR1a and CTR1b, as well as two homologs to Cryptococcus neo

SUBMITTER: Anne S 

PROVIDER: S-EPMC12113139 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature