Associations of <i>PPARG</i> and <i>PPARGC1A</i> Polymorphisms with Ritodrine-Induced Adverse Events in Patients with Preterm Labor.

ABSTRACT: Objectives: Ritodrine, a tocolytic agent used to delay preterm labor, can cause several cardiovascular-associated adverse events (AEs). This study aimed to examine the relationship between gene polymorphisms in peroxisome proliferator-activated receptor gamma (PPARG) and PPARG coactivator-1α (PPARGC1A) and the occurrence of ritodrine-induced AEs. Additionally, a risk-scoring system was developed to identify patients at high risk of AEs. Methods: Patients aged 18 years or older who were administered ritodrine to manage preterm labor with intact membranes and uterine contractions occurring at 20-36 weeks of gestation were enrolled in this study. A total of 70 common PPARG and PPARGC1A variants (minor allele frequency ≥ 0.2) with low linkage disequili

SUBMITTER: Jang EJ 

PROVIDER: S-EPMC12113205 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature