Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer.

ABSTRACT: Background/Objectives: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks the sensitivity to detect micrometastatic disease. The functional assessment of NSCLC progression may provide independent information to enhance the prediction of metastatic risk. The objective of this study was to determine if we could identify a metabolomic signature predictive of metastasis in patients with NSCLC treated with definitive radiation. Methods: Plasma samples were collected prospectively from patients enrolled in a clinical trial with non-metastatic NSCLC treated with definitive radiation. Metabolites were extracted, and mass spectrometry-based analysis was performed using a flow injection electrospray (FIE)-Fourier transform ion cyclotro

SUBMITTER: Liu M 

PROVIDER: S-EPMC12113581 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature