Purpuramine R, a New Bromotyrosine Isolated from <i>Pseudoceratina</i> cf. <i>verrucosa</i> Collected in the Kingdom of Tonga.

ABSTRACT: Sponges in the verongiid genus Pseudoceratina Carter are well-known producers of bioactive secondary metabolites. Chemical screening of a Tongan P. cf. verrucosa Bergquist using NMR highlighted the presence of aromatic natural products. Subsequent extraction and purification of P. cf. verrucosa yielded a new bromotyrosine, purpuramine R (1), that exhibits moderate (MIC 16 µg/mL) antibacterial activity against Gram-positive Staphylococcus aureus. The E-geometry of the oxime was confirmed using a combination of NMR and computational approaches. Additionally, computational conformational analysis indicates that purpuramine R adopts a hairpin orientation, stabilized by intramolecular hydrogen and halogen bonds. Knowledge of this stabilize

SUBMITTER: Ramirez-Garcia JL 

PROVIDER: S-EPMC12113617 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature