Causal association between body mass index and risk of colon polyps: A Mendelian randomization study.

ABSTRACT: The relationship between obesity and colorectal polyps remains inconclusive. This study aimed to examine whether body mass index (BMI) is causally associated with colon polyps. A two-sample Mendelian randomization (MR) analysis using the inverse variance weighted, weighted median and MR-Egger regression methods was performed. We used the publicly available summary statistics data sets of genome-wide association studies (GWAS) meta-analyses for BMI in individuals of European descent (n = 322,154; GIANT consortium) as the exposure and a GWAS for colon polyps included in the UK Biobank (total n = 463,010; case = 4779, control = 458,231) as the outcome. We selected 76 single nucleotide polymorphisms at genome-wide significance from GWASs on BMI as the instrumental variables. The inverse varian

SUBMITTER: Ning XJ 

PROVIDER: S-EPMC12113971 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature