First Report of <i>Streptococcus agalactiae</i> Meningitis in a Non-Pregnant Adult in Italy.

ABSTRACT: This study, for the first time in Italy, analyses by WGS a Streptococcus agalactiae strain isolated from a non-pregnant adult affected by Meningitis and without common risk factors. The S. agalactiae strain was classified as a serotype II (SS2), sequence type ST569. Molecular characterization evidenced the presence of resistance genes to tetracycline and macrolide (tet(M) and mre(A)) and several virulence genes coding for adhesion and immune evasion factors (bca, cps family, neu family, scpB, gbs family, pil family and hylB), toxins (cfa/cfb, cyl family), pro-inflammatory factors (lepA), and two homologous genes that contributed to bacterial escape from the host immune system (lmb, l

SUBMITTER: Borriello G 

PROVIDER: S-EPMC12114074 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature