Characterization of Terpene Synthases Reveals the Diversity of Terpenoids in <i>Andrographis paniculata</i>.

ABSTRACT: Terpenoids have significant biological activity and good clinical efficacy and are important for defence and physiological regulation in plants. Andrographolide and similar labdane-related diterpenoids have been isolated and characterized as the main medicinal constituents of drugs from Andrographis paniculata. To better study the diversity of terpenoids of A. paniculata, a total of 39 ApTPSs were screened, and 27 full-length genes encoding ApTPSs were obtained. The results showed that ApTPS4 could convert GGPP to ent-CPP and that ApTPS5 could convert ent-CPP to kaurene. This study first identified six sesquiterpene synthases with biological activity and also indicated the presence of sesquiterpenes with multiple skeletons in A. paniculata. The inc

SUBMITTER: Tang J 

PROVIDER: S-EPMC12114178 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature