Non-Secretor Status Due to <i>FUT2</i> Stop Mutation Is Associated with Reduced Rotavirus Infections but Not with Other Enteric Pathogens in Rwandan Children.

ABSTRACT: Enteric pathogens remain a health threat for children in low-income countries. A single nucleotide polymorphism (SNP) in the FUT2 gene that precludes the expression of fucosyltransferase 2 has been reported to influence the susceptibility to rotavirus and norovirus infections. The aim of this study was to investigate the association between G428A at rs601338 (stop codon variant) in the FUT2 gene and a range of enteric pathogens in children under 5 years of age. Rectal swab samples from 668 children (median age 13.6 months, 51% males, 93% rotavirus vaccinated, 468 with diarrhea) from Rwanda were analyzed via PCR for pathogen detection and SNP genotyping. A FUT2 stop codon ('non-secretor' status) was found in 19% of all children. Rotavirus was detected in 5.3% of

SUBMITTER: Munyemana JB 

PROVIDER: S-EPMC12114204 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature